个人简介：

作为项目主持人共承担有3项国家自然科学基金项目，3项省部级科研项目及1项广州市科技计划项目；并以第二负责人的身份参与了多项省级、国家级项目。以第一作者或通讯作者在Nat Commun、Chem. Eng. J.、Theranostics、Bioactive Materials、ACS Appl Mater Interfaces、Anal. Chem.、Nanoscale等权威杂志发表SCI论文近40篇，影响因子大于5的有19篇；论文共被引用2300多次，H因子为23（Google Scholar）。授权国家发明专利4项，实用新型2项。参与编写英文专著2本。中国生物医学工程学会会员及中国光学学会会员，同时担任国家自然科学基金及广东省自然科学基金评审专家，以及多个权威学术期刊（如：Nat Commun、Adv Mater、Nano Lett、Nano-Micro Lett、Theranostics、Biosens Bioelectron、Nanoscale、ACS Appl Mater Interfaces、Chem Comm、J Mater Chem B、Nanomedicine等）审稿人。

研究方向：

拉曼光谱技术的生物医学应用研究：生理及病理机制的新方法解析、微生物检测、新型SERS基底设计与构建；

病原微生物快检技术的光学解决方案；

无机纳米材料的光学特性研究及其诊疗应用。

工作经历：

2013.9-至今 华南师范大学生物光子学研究院 讲师、副研究员。

学习经历：

2010.9—2013.6 华南师范大学生物光子学研究院博士，获理学博士学位；

2007.9—2010.6 华南师范大学生物光子学研究院研究生，获理学硕士学位；2003.9—2007.6 福建师范大学生命科学学院本科, 获工学学士学位。

2021

[1]     Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics. Bioactive Materials. 2021, 6, 655.  (共一)  SCI, IF: 8.724

2020

[2]     In situ Photothermal Activation of Necroptosis Potentiates Black Phosphorus-Mediated Cancer Photo-Immunotherapy. Chem. Eng. J. 2020, 394, 124314.  (通讯作者) SCI, IF: 10.652

[3]     Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO₂ nanoaggregates. Sci. China Mater. 2020, 63, 1085.  (通讯作者) SCI, IF: 6.098

[4]     SERS analysis of carcinoma-associated fibroblasts in a tumor microenvironment based on targeted 2D nanosheets. Nanoscale. 2020, 12, 2133.  (通讯作者) SCI, IF: 6.895

[5]     Photo-induced synthesis of molybdenum oxide quantum dots for surface-enhanced Raman scattering and photothermal therapy. J. Mater. Chem. B. 2020, 8, 1040.  (通讯作者) SCI, IF: 5.344

[6]     Few-Layer NbTe2 Nanosheets as Substrates for Surface-Enhanced Raman Scattering Analysis. ACS Applied Nano Materials. 2020, 3, 11363.

[7]     Rapid label-free SERS detection of foodborne pathogenic bacteria based on hafnium ditelluride-Au nanocomposites, J. Innov. Opt. Heal. Sci. 2020, 13, 2041004.  (封面论文，通讯作者) SCI, IF: 1.661

[8]     Morphology-controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer. ChemNanoMat. 2020, 6, 1407.  (通讯作者) SCI, IF: 3.384

[9]     Facile synthesis of metal-phenolic-coated gold nanocuboids for surface-enhanced Raman scattering. Appl Opt. 2020, 59, 6124.  (通讯作者) SCI, IF: 1.961

2019

[10]  Hydrophobic carbon dots with blue dispersed emission and red aggregation-induced emission. Nature Communications 2019, 10, 1789.  (通讯作者) SCI, IF: 12.121

[11]  Facile hot spots assembly on molybdenum oxide nanosheets via in situ decoration with gold nanoparticles. Appl. Surf. Sci. 2019, 480, 1162.  (通讯作者) SCI, IF: 6.182

[12]  Black phosphorus-Au filter paper-based three-dimensional SERS substrate for rapid detection of foodborne bacteria. Appl. Surf. Sci. 2019, 497, 143825.  (通讯作者) SCI, IF: 6.182

[13]  Biodegradable black phosphorus-based nanomaterials in biomedicine: Theranostic applications. Curr Med Chem. 2019, 26, 1788.  (通讯作者) SCI, IF: 4.184

[14]  Molybdenum oxide nano-dumplings with excellent stability for photothermal cancer therapy and as a controlled release hydrogel. New J. Chem. 2019, 43, 14281.  (通讯作者) SCI, IF: 3.288

[15]  Black phosphorus-polypyrrole nanocomposites for high-performance photothermal cancer therapy. New J. Chem. 2019, 43, 8620.  (通讯作者) SCI, IF: 3.288

[16]  Full-scale label-free surface-enhanced Raman scattering analysis of mouse brain using a black phosphorus-based two-dimensional nanoprobe. Appl. Sci. 2019, 9, 398  (通讯作者) SCI, IF: 2.474

2018

[17]  A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy. Nanoscale 2018, 10, 18795.  (通讯、第一作者) SCI, IF: 6.895

[18]  Insights into the intracellular behaviors of black-phosphorus-based nanocomposites via surface-enhanced Raman spectroscopy. Nanophotonics 2018, 7, 1651.  (通讯作者) SCI, IF: 7.491

[19]  Investigating the autophagy pathway in silver@gold core–shell nanoparticles-treated cells using surface-enhanced Raman scattering. Analyst 2018, 143, 3677.  (通讯作者) SCI, IF: 3.978

[20]  Phase-controlled synthesis of molybdenum oxide nanoparticles for surface enhanced Raman scattering and photothermal therapy. Nanoscale 2018, 10, 5997.  (通讯作者) SCI, IF: 6.895

2017

[21]  Multifunctional Nanoplatform Based on Black Phosphorus Quantum Dots for Bioimaging and Photodynamic/Photothermal Synergistic Cancer Therapy, ACS Appl. Mater. Interfaces 2017, 9, 25098.  (通讯作者) SCI, IF:8.758

[22]  Facile synthesis of black phosphorus-Au nanocomposites for enhanced photothermal cancer therapy and surface-enhanced Raman scattering analysis, Biomater. Sci. 2017, 5, 2048.  (共一) SCI, IF: 6.183

[23]  Development of graphene oxide-wrapped gold nanorods as robust nanoplatform for ultrafast near-infrared SERS bioimaging, Int. J. Nanomed. 2017, 12, 4349.  (通讯作者) SCI, IF: 5.115

[24]  Melanin-Associated Synthesis of SERS-Active Nanostructures and the Application for Monitoring of Intracellular Melanogenesis, Nanomaterials 2017, 7, 70.  (通讯作者) SCI, IF: 4.324

[25]  Biological pH sensing based on the environmentally friendly Raman technique through a polyaniline probe, Anal. Bioanal. Chem. 2017, 409, 1387.  (通讯作者) SCI, IF: 3.637

[26]  One-pot green synthesis of flower-liked Au NP@GQDs nanocomposites for surface-enhanced Raman scattering, J. Alloy. Compd. 2017, 725, 1084.  (共一) SCI, IF: 4.65

[27]  Synthesis of Au NP@MoS2 quantum dots core@shell nanocomposites for SERS bio-analysis and label-free bio-imaging. Materials. 2017, 10, 650.  (通讯作者) SCI, IF: 3.057

Before 2016

[28]  Fabrication of Graphene and AuNP Core Polyaniline Shell Nanocomposites as Multifunctional Theranostic Platforms for SERS Real-time Monitoring and Chemo-photothermal Therapy. Theranostics 2016, 6, 1096. (通讯作者) SCI, IF: 8.579

[29]  Dye-free near-infrared surface-enhanced Raman scattering nanoprobes for bioimaging and high-performance photothermal cancer therapy. Nanoscale 2015, 7, 6754. (通讯、第一作者)  SCI, IF: 6.97

[30]  A facile one-pot method to two kinds of graphene oxide-based hydrogels with broad-spectrum antimicrobial properties. Chem. Eng. J. 2015, 260, 331.  (通讯作者) SCI, IF: 10.652

[31]  Polyaniline nanoparticles: potential optical coherence tomography contrast agents. Journal of Optical Technology. 2015, 82, 639  (共一) SCI, IF: 0.416

[32]  Mitochondrial-Targeted Polyethylenimine Functionalized Graphene Oxide Nanocarrier and its Anti-Tumor Effect on Human Lung Carcinoma Cells. NANO. 2015, 10, 1550121  (共一) SCI, IF: 1.566

[33]  Rapid intracellular growth of gold nanostructures assisted by functionalized graphene oxide and its application for surface-enhanced Raman spectroscopy. Anal. Chem. 2012, 84, 10338.  (第一作者) SCI, IF: 6.785

[34]  In situ green synthesis of silver-graphene oxide nanocomposites by using tryptophan as a reducing and stabilizing agent and their application in SERS. Appl. Surf. Sci. 2014, 316, 22.  (第一作者) SCI, IF: 6.182

[35]  Graphene oxide based surface-enhanced Raman scattering probes for cancer cell imaging. Phys. Chem. Chem. Phys. 2013, 15, 2961.  (第一作者) SCI, IF: 3.43

[36]  Cellular distribution and cytotoxicity of graphene quantum dots with different functional groups. Nanoscale Res. Lett. 2014, 9, 108.  (第一作者) SCI, IF: 3.581

[37]  pH-dependent surface-enhanced Raman scattering of aromatic molecules on graphene oxide. J. Raman Spectrosc. 2013, 44: 75-80.  (第一作者) SCI, IF: 2

[38]   Conformation-dependent surface-enhanced Raman scattering of graphene oxide/metal nanoparticle hybrids. Chin. Opt. Lett. 2013, 11, 083001.  (第一作者) SCI, IF: 2.045

[39]  Quantitative optical coherence tomography of skin lesions induced by different ultraviolet B sources. Phys. Med. Biol. 2010, 55, 6175.  (第一作者) SCI, IF: 2.883

出版著作

1.        Zhiming Liu and Zhouyi Guo, Applications of Graphene-Based Nanomaterials in Cancer Research, In: Boveri R, editor. Graphene Oxide: Synthesis, Mechanical Properties and Applications. Nova Science Publishers, New York, USA, 2014: 33-66. URL: www.novapublishers.com

2.        Yanxian Guo, Zhiming Liu, Wen Zhang and Zhouyi Guo, New advances in graphene oxide-metal nanocomposites for cancer theranostics. In: Ajay Kumar Mishra and Deepak Pathania, editors. Graphene Oxide: Advances in Research and Applications. Nova Science Publishers, New York, USA, 2018: 61-86. URL: www.novapublishers.com

授权发明专利

1)       刘智明, 郭周义, 黄汉传, 一种黑磷-金属纳米复合材料及其合成方法和应用, 中国，2019.07.05，ZL201610928015.3.

2)       刘智明, 郭周义, 一种NIR SERS探针及其制备方法和应用, 中国，2017.01.04，ZL201410178898.1.

3)       刘智明, 郭周义, 一锅法合成海胆状金纳米粒子和球状聚苯胺的方法及应用, 中国，2018.02.23, 专利号: ZL201510944293.3.

4)       刘智明, 杨辉, 周艳, 郭周义, 叶丙刚, 陈浩琳, 李颂扬, 龙佳, 林锦, 一种细胞内黑色素的快速检测与成像的方法, 中国，2018.02.16， ZL201410513894.4.

5)       刘智明, 郭周义, 一种用于SERS检测的试样过滤装置, 中国，2019.03.22，ZL201820769774.4.

1)       国家自然科学基金面上项目，No. 32071399，碳点支持金属SERS探针诱导癌相关成纤维细胞自噬机制及抗肿瘤研究，2021/01-2024/12，主持。 

2)       国家自然科学基金面上项目，No. 11874021，NIR-Ⅱ及拉曼双响应型氧化钼基纳米探针的肿瘤诊疗一体化研究，2019/01-2022/12，主持。

3)       国家自然科学基金青年科学基金项目，No. 21505047，以聚苯胺为活性分子的低毒型近红外SERS标记的构建及其pH传感能力研究，2016/01-2018/12，主持。

4)       广东省自然科学基金面上项目，金-碳纳米点核壳结构诱导细胞自噬分子机制的表面增强拉曼光谱研究，2021/01-2023/12，主持（已立项）。

5)       广东省省级科技计划项目，No. 2017A020215059，食源性致病菌的快速非标记SERS检测及鉴别新技术研究，2017/01-2018/12，主持。

6)       广东省自然科学基金博士启动项目，No. 2014A030310306，具有表面增强拉曼活性的导电聚合物-金属纳米复合材料的构建及其在肿瘤光热治疗中的应用研究，2015/01-2018/01，主持。

7)       广州市科技计划项目，No. 201904010323，欠氧型氧化钼纳米材料的表面增强拉曼效应及其生物应用研究，2019/04-2022/03，主持。

8)       医学光电科学与技术教育部重点实验室（福建师范大学）开放课题，No. JYG2009，基于长余辉碳点荧光探针的ACE2靶向细胞成像研究，2019/09-2022/08，主持。

9)       华南师范大学青年教师培育基金，No. 14KJ10，以金纳米棒为核的近红外表面增强拉曼标记的制备及其在乳腺癌光热治疗中的应用，2015/01-2016/12，主持。

10)    国家自然科学基金面上项目，No. 61675072，具有SERS活性的Sp3杂化型二维纳米材料的构建及其在肿瘤成像及光疗中的应用研究，2017/01-2020/12，排名第二。

11)    广东省自然科学基金重点项目，No. 2014A030311024，适用于光学成像导向的脑肿瘤治疗的多功能石墨烯纳米复合物构建研究，2015/01-2018/01，排名第二。

12)    国家自然科学基金面上项目，No. 61275187，基于光学成像技术的石墨烯-金属复合物在肿瘤化疗联合近红外光热疗法中的应用研究，2013/01-2016/12，排名第二。

13)    横向项目（无限极中国有限公司），No. HPG/2013/11/1598 ，微激光若干应用关键技术开发研究，子课题一：“微激光作为皮肤保健调理工具的可行性研究”，2014/01-2015/05，100万，负责人。