邓小元，女，研究员，博导。广东省“千百十工程”省级培养对象（第四批）, 华南师范大学“三级教授”。本科和硕士期间一直从事机械相关专业的学习及科研；博士期间师从唐孝威学部委员，开始从事医学物理的研究，主要是核磁共振（MRI）成像模式的医学应用。自2000年在澳大利亚开始为期三年的博士后工作，主要从事生物组织的双光子荧光（Two-Photon Fluorescence，TPF）和二次谐波(Second-Harmonic Generation，SHG)非线性光学显微成像技术及其在生物医学方面的应用，在活体组织、细胞及结构蛋白的非线性光学成像领域取得了深厚的理论基础和实验经验。近年来进一步开展生物医学纳米材料及纳米光学探针研究。主持4项国家自然科学基金，以第一及通讯作者在国际重要学术刊物发表相关SCI收录论文三十余篇，其中包括如Advanced Functional Materials (IF19.924，Q1), Biomaterials (IF15.304，Q1）, ACS Applied Materials & Interfaces (IF10.383，Q1）（2篇）, Nanoscale（IF8.307，Q1）, Stem Cell Research & Therapy(IF8.079，Q2）（2篇）, Journal of Biomedical Optics (Q2）（4篇）, Journal of Applied Physics (Q2）（2篇）， Applied Optics (Q2）（2篇）等国际权威刊物十几篇。与世界著名光学专家“Min Gu”教授（澳大利亚工程及科学院院士）共同完成一部由世界知名出版社Springer出版（978-3-662-46396-3）的涉及生物医学物理、生物医学工程领域的相关原创性学术专著《Microscopic Imaging Through Turbid Media》（Min Gu, Xiaosong Gan, Xiaoyuan Deng）。

教育资历:

  1995/9–1998/8 理科博士(粒子物理)中国科学院高能物理研究所, 北京

  博士论文: Alzheimer病的核磁共振影像定量研究 — 数理统计分析及人工神经网络分析

  1991/9–1994/3 工程硕士(机械学)北京理工大学机械工程系，北京

  硕士论文: 可倾瓦气体动压轴承参数优化及应用研究

  1985/9–1989/8 工程学士(机械制造工艺及设备)

  武汉理工大学, 武汉, 中国

职业经历:

  2016/11 -至今，研究员，华南师范大学，生物光子学研究院

  2010/1-2016/10， 副主任华南师范大学实验中心 负责核磁共振成像（MRI）超大型设备购置、安装及运行管理

  2009.1-2009.12，研究员，华南师范大学生物光子学研究院

  2004.12-2008.12，研究员，

  2004/7–2004/11，副教授，华南师范大学信息光电子科技学院

  2003/4–2003/7，项目负责人，Centre for Micro-Photonics, Swinburne University of Technology, Australia

  2000/4–2003/4，博士后/光学&光电子学，Centre for Micro-Photonics, Swinburne University of Technology, Australia

  1998/9–2000/3，博士后/光学&光电子学，华南师范大学激光生命科学研究所，广州，中国

以第一或通讯作者发表主要相关SCI期刊论文（2002-至今）

1. Yongzhen Yang, Qin Wang, Gongjian Li, Wenjing Guo, Zuojun Yang, Hao Liu and Xiaoyuan Deng*, Cysteine-derived chiral carbon quantum dots: a fibrinolytic activity regulator for plasmin to target the human islet amyloid polypeptide for type 2 diabetes mellitus, ACS Applied Materials & Interfaces 15：2617-2629 (2023)

2. Danyang Liang, Yongzhen Yang , Gongjian Li, Qin Wang, Heting Chen and Xiaoyuan Deng*，Endogenous H₂O₂-Sensitive and Weak Acidic pH-Triggered Nitrogen-Doped Graphene Nanoparticles (N-GNMs) in the Tumor Microenvironment Serve as Peroxidase-Mimicking Nanozymes for Tumor-Specific Treatment，Materials 14: 1933 (2021)

3. Wei Lin, Xiaoyang Qi, Wenjing Guo, Danyang Liang, Heting Chen, Baopin Lin, Xiaoyuan Deng*, A barrier against reactive oxygen species: chitosan/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing, Stem Cell Research & Therapy 11:383 (2020)

4. Xiaoyang Qi, Hanping Liu, Wenjing Guo, Wei Lin, Baoping Lin, Ying Jin,*and Xiaoyuan Deng*, New Opportunities: Second Harmonic Generation of Boron-Doped Graphene Quantum Dots for Stem Cells Imaging and Ultraprecise Tracking in Wound Healing, Advanced Functional Materials 1902235 (2019)

5. Baoping Lin, Heting Chen, Danyang Liang, Wei Lin, Xiaoyang Qi, Hanping Liu* and Xiaoyuan Deng*, Acidic pH and High‑H₂O₂ Dual Tumor Microenvironment-Responsive Nanocatalytic Graphene Oxide for Cancer Selective Therapy and Recognition, ACS Applied Materials & Interfaces 11: 11157-11166 (2019)

6. Chengmin He, Zhi Yang, Ying Jin, Xiaoyang Qi, Jin Chu and Xiaoyuan Deng*, ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1, frontiers in Physiology 9: 657 (2018)

7. Zhi Yang, Chengmin He, Jinyang He, Jing Chu, Hanping Liu* and Xiaoyuan Deng*，Curcumin-mediated bone marrow mesenchymal stem cell sheets create a favorable immune microenvironment for adult full-thickness cutaneous wound healing，Stem Cell Research & Therapy 9: 1-18（2018）

8. Jing Chu, Panpan Shi, Wenxia Yan, Jinping Fu, Zhi Yang, Chengmin He, Xiaoyuan Deng* and Hanping Liu*, PEGylated graphene oxide-mediated quercetin modified collagen hybrid scaffold for enhancement of MSCs differentiation potential and diabetic wound healing, Nanoscale 10: 9547-9560 (2018)

9. Jing Chu, Panpan Shi, Xiaoyuan Deng*, Ying Jin, Hao Liu, Maosheng Chen, Xue Han, Hanping Liu*, Dynamic multiphoton imaging of acellular dermal matrix scaffolds seeded with mesenchymal stem cells in diabetic wound healing, J. Biophotonics 11：e201700336 (2018)

10. Ning Wang, Hanping Liu, Xuefeng Li, Qilei Zhang, Maosheng Chen, Ying Jin*, Xiaoyuan Deng*, Activities of MSCs Derived from Transgenic Mice Seeded on ADM Scaffolds in Wound Healing and Assessment by Advanced Optical Techniques, Cellular Physiology and Biochemistry 42：623-639 (2017）

11. Ning Wang, Huajiang Wei, Ying Jin, Lianzhou Chen, Qilei Zhang, Xiaoyuan Deng* Monitoring Skin Trauma Healing in Mice Using Second-Harmonic Generation Combined with Optical Coherence Tomography, IEEE Photonics Journal 9：3700112 （2017）

12. Maosheng Chen, Ying Jin, Xue Han, Ning Wang, Xiaoyuan Deng* and Hanping Liu*, MSCs on an Acellular Dermal Matrix (ADM) Sourced from Neonatal Mouse Skin Regulate Collagen Reconstruction of Granulation Tissue during Adult Cutaneous Wound Healing, RSC Advances 7: 22998-23010 (2017)

13. Xue Han, Hanping Liu, Maosheng Chen, Li Gong, Hongwen Pang, Xiaoyuan Deng* and Ying Jin*, Acellular Dermal Matrix from One-Day-Old Mouse Skin on Adult Scarless Cutaneous Wound Repair by Second Harmonic Generation Microscopic Imaging, RSC Advances 6: 71852-71862 (2016)

14. Fangqin Guo, Yan Hu, Lianyuan Yu, Xiaoyuan Deng*, Jie Meng*, Chen Wang*, and Xian-Da Yang*，Enhancement of Thermal Damage to Adenocarcinoma Cells by Iron Nanoparticles Modified with MUC1 Aptamer, Journal of Nanoscience and Nanotechnology 16: 2246–2253 (2016)

15. Qiannan Wang, Ying Jin*, Xiaoyuan Deng*, Hangping Liu, Hongwen Pang, Panpan Shi, Zhigang Zhan, Second-Harmonic Generation Microscopy for Assessment of Mesenchymal Stem-Cell Seeded Acellular Dermal Matrix in Wound Healing, Biomaterials 53: 659-668 (2015)

16. Jianmei Liu, Ying Jin, Hanping Liu, Feifei Wang and Xiaoyuan Deng*, The Forward and Backward Second-Harmonic Generation from Crystallized Collagen Fibre with Tightly Focused Linearly Polarized Beams, Journal of Optics A: Pure and Applied Optics 14: 055301 (2012)

17. Fei Fei Wang, Jianmei Liu and Xiaoyuan Deng*, The Influence of the Orientation of the Collagen Dipoles on Second Harmonic Generation (SHG) with High NA under Crystallized Type I Collagen Fiber Model, International Journal of Modern Physics B 26: 1250148 (2012)

18. Long Tian, Huajiang Wei, Ying Jin, Hanping Liu, Zhouyi Guo, Xiaoyuan Deng*, Backward Emission of Microscopic Second-Harmonic Generation (SHG) from Crystallized Type I Collagen Fiber, Journal of Biomedical Optics 16: 075001 (2011)

19. Y. Chang, H. Wei, Y. Jin, H. Liu & X. Deng*, Microscopic Second Harmonic Generation (SHG) from Tilt-Placed Collagen Fibrils, General Physiology & Biophysics 30: 175–185 (2011).

20. Long Tian, Junle Qu, Zhouyi Guo, Yin Jin, Yaoyong Meng, and Xiaoyuan Deng*, Microscopic Second-Harmonic Generation Emission Direction in Fibrillous Collagen Type I by Quasi-Phase-Matching Theory, Journal of Applied Physics 108: 054701 (2010)

21.Ying Chang, Xiaoyuan Deng*, Characterization of Excitation Beam on Second-Harmonic Generation in Fibrillous Type I Collagen, Journal of Biological Physics 36: 365-383 (2010)

22. Zhengfei Zhuang, Hanping Liu, Zhouyi Guo, Biying Yu, Shuangmu Zhuo, Xiaoyuan Deng*, Second-Harmonic Generation (SHG) as a DNA Malignancy Indicator of Prostate Glandular Epithelial Cell, Chinese Physics B 19: 04XXXX-1~04XXXX-5 (2010)

23. Ying Chang, Changshui Chen, Jianxin Chen, Ying Jin, Xiaoyuan Deng*, Theoretical Simulation Study of Linearly Polarized Light on Microscopic Second Harmonic Generation (SHG) in Collagen Type I, Journal of Biomedical Optics 14: 044016 (2009)

24. Hanping Liu, Zhengfei Zhuang, Lingling Zhao, Junle Qu and Xiaoyuan Deng*, Study of van Gieson’s (VG) picrofuchsin staining on second-harmonic generation (SHG) in type I collagen, Chinese Optics Letters 6: 882-885 (2008)

25.Xiaoyuan Deng*, Xianju Wang, Hanping Liu, Zhengfei Zhuang, Zhouyi Guo, The effect of distribution pattern of molecular dipoles on microscopic second-harmonic generation, Chinese Physics Letters 23: 629 - 632 (2006)

26.Xiaoyuan Deng*, Xianju Wang, Hanping Liu, Zhengfei Zhuang, Zhouyi Guo, Simulation study of second-harmonic microscopic imaging signals through tissue-like turbid media. Journal of Biomedical Optics 11: 024013 (2006)

27.Xiaoyuan Deng, Xiaosong Gan and Min Gu*, Effective Mie Scattering of a spherical fractal aggregate and its application in turbid media. Applied Optics 43: 2925~2929 (2004)

28.Xiaoyuan Deng, Xiaosong Gan, Min Gu*, Monte-Carlo Simulation of Multi-photon Fluorescence Microscopic Imaging through Inhomogeneous Tissue-like Turbid Media. Journal of Biomedical Optics 8: 440 ~ 449 (2003)

29.Xiaoyuan Deng, Min Gu*, Penetration depth of single-, two-, three-photon fluorescence microscopic imaging through human cortex structures: Monte Carlo simulation. Applied Optics 42:  3321~3329 (2003)

30.Xiaoyuan Deng, Xiaosong Gan, Min Gu*, Multi-photon fluorescence microscopic imaging through double-layer tissue media. Journal of Applied Physics 91: 4659 ~ 4665 (2002)

31. Xiaoyuan Deng, Elizabeth D Williams, Erik W. Thompson, X. Gan, Min Gu*, Second-harmonic generation from biological tissues: effect of excitation wavelength. Scanning 24: 175~178 (2002)

专利

邓小元，漆晓阳，产生二次谐波的掺杂石墨烯量子点及其制备方法和应用（专利号：ZL 2018 1 0404227.0；授权公告号CN 108559497 B）

附：早期发表的与核磁共振影像相关论文

1. Xiaoyuan Deng, Kuncheng Li, Shuliang Liu, Preliminary study of the application of Artificial Neural Network in the diagnosis of Alzheimer disease through Magnetic Resonance Imaging. Chinese Medical J. Vol. 112, No. 3, P. 232-237 (1999)

2. 邓小元, 李坤成, 刘树良, Alzheimer病MRI诊断测量研究. 中国医学影像技术, Vol.15, No.7, P. 508-511 (1999)

3. 邓小元, 李坤成, Alzheimer病的MRI形态学测量研究进展. 中华放射学杂志, Vol.32, No.2, P.803-806 (1998)

4. 邓小元, 李坤成, 刘树良,人工神经网络在Alzheimer病的MRI诊断研究中的应用.中华放射学杂志, Vol.32, No.2, P.812-816 (1998)

学术专著：

Min Gu, Xiaosong Gan, Xiaoyuan Deng, Microscopic Imaging Through Turbid Media, Springer, 2015, Published（ISBN 978-3-662-46396-3, Physics ISSN 1618-7210）

科研项目：

1. 干细胞基质（ECM）壁龛调控皮肤无疤重建机理的多光子成像研究 （国家自然科学基金No.81671729）（2017.1～2020.12）（主持）

2. 广州市光谱分析与功能探针重点实验室建设项目（广州市科技局No.201805010002）（2018.04-2020.03）（核心成员参与）

3.  多模式非线性显微光学3D成像应用于干细胞移植皮肤再生的生理机理研究（国家自然科学基金No.81171379）(2012.1～2015.12) （主持）

4.  间充质干细胞（MSC）移植皮肤再生机理的活体在位非线性光学成像研究（国家自然科学基金主任基金No.30940020）(2010.1～2010.12) （主持）

5.  二次谐波非线性光学显微成像用于前列腺癌的诊断及药物疗效初探 (2005.1～2007.12 )（国家自然科学基金No.30470495） （主持）

6.  混浊介质中显微成像(2001～2003) (澳大利亚研究委员会)  （参与）

7.  非线性光学扫描成像用于早期癌症探测 (2001～2003)(澳大利亚研究委员会) （参与）

8.  光子密度波在乳房癌探测中的模拟研究 (1999～2000) (广东省博士后基金) （主持）

9.  正常和非正常生物组织中光子密度波的模拟研究(1999～2000)(广东省高等教育局科技基金) （主持）

10. 国家攀登计划B:核医学和放射治疗中先进技术的基础研究之子课题 脑功能成像中的先进技术研究 (国家科学技术委员会) (1995～1998) （参与）

11.  气体润滑动压轴承在废气蜗轮增压器中的应用之子课题:动态可倾瓦气体推理轴承的参数优化及应用 (1991～1994) ( 国家自然科学基金) （参与）